Drug Metabolite Profiling
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Full Data Set Peak Picking and Identification
Full Data Set Automated Peak Picking at any resolution and sensitivity. Use un-targeted and targeted accurate quantitation detection with or without Mass Defect Filtering.
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High Resolution Isotope Pattern Filtering – Low Level Reactive Metabolite Detection
Use High Resolution Isotope Pattern Filtering (IPF) to detect metabolites having natural (Cl, Br) or a synthetically introduced isotope pattern (GSH Trapping, 12C/13C, 12C/14C etc). Can be used in combination with Mass Defect Filtering and control Background Subtraction.
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High Resolution Differential Analysis: Find Unique Peaks in your Sample not Present in the Control
Use high resolution peak detection for an untargeted approach, followed by a sensitive comparison of all detected peaks with one or more control samples.
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IHumite: Identification of Human Metabolites, an Integrated Prediction based Approach
iHumite, developed by TNO triskelion, MsMetrix and MSandMore, delivers complete profiling of major “>10%” plasma metabolites already in First-in-Man study. iHumite reduces the risk of new metabolite findings and delay in clinical phase III 14C studies.
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Drug Metabolite Profiling: Species Comparison
Quickly find all major metabolites in the human samples and quantitate the detected relevant peaks in all other species from your study in one step. Use multivariate tools like Principal Components Analysis (PCA) to see which species most resemble the “human” profile.
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